General Information

  • ID:  hor001144
  • Uniprot ID:  A0A7M7L8Y0
  • Protein name:  TWKSPDIVIRFa–FMRFa-like
  • Gene name:  100578542
  • Organism:  Apis mellifera (Honeybee)
  • Family:  FMRFamide related peptide family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Apis (genus), Apini (tribe), Apinae (subfamily), Apidae (family), Apoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  TWKSPDIVIRF
  • Length:  11
  • Propeptide:  MSCLSSLYVLPFICNCVLVSSSVLTTLKTDGGLRIFKDAPNEFKDVPNEFEEALKRHSIDCHSDKRENPQGCSGSFFVRDERSDPDRGKERFYNGDGDRGSNRSPRTWKSPDIVIRFGRAGFKNLNREQKRGRNDLNFIRYGRGMQIYPDSVVTAICSNLLSNEDIQPYEARLLRFCNCLNNNDVDHRENLDFFEDRLGTKHD
  • Signal peptide:  MSCLSSLYVLPFICNCVLVSS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A7M7L8Y0-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001144_AF2.pdbhor001144_ESM.pdb

Physical Information

Mass: 154015 Formula: C65H100N16O16
Absent amino acids: ACEGHLMNQY Common amino acids: I
pI: 9.69 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 5
Hydrophobicity: 0.91 Boman Index: -1597
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 97.27
Instability Index: 2080 Extinction Coefficient cystines: 5500
Absorbance 280nm: 550

Literature

  • PubMed ID:  19576913
  • Title:  Mass Spectrometric Profiling of (Neuro)-Peptides in the Worker Honeybee, Apis Mellifera